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Category:Can-Am Category:Motorcycle manufacturers of the United States Category:Electric motorcycles Category:Motor vehicle manufacturers based in Michigan Category:American brands Category:2005 establishments in Michigan Category:Companies based in Michigan Category:Motorsport in the United StatesExpression of a functional-like P2Y12 receptor in human epithelial cells of the airway. P2Y12 receptor is an important receptor for the platelet agonist adenosine diphosphate (ADP), a molecule present at high concentration in the airways. The aim of this work was to investigate the possibility of P2Y12 receptor expression and function in human epithelial cells of the airways. Cell-specific expression of P2Y12 receptor was demonstrated by reverse transcription-polymerase chain reaction, Northern blotting, and ligand binding analyses. The P2Y12 receptor on human airway epithelial cells was functional as assessed by phospholipase C and PLCγ activation and calcium mobilization. As shown by Western blot analysis, the number of P2Y12 receptors on cell surface was not affected by activation. The results suggest that P2Y12 receptor might participate in the pathophysiology of airway remodeling, and its specific blockers might prevent or modify the course of airway remodeling. Debug AnyCPU 8.0.30703 2.0 {D6FC0B52-5CC2-4046-891E-0ABA5CF99A7E} {EFBA0AD7-5A72-4C68-AF49-83D382785DCF};{FAE04EC0-301F
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